New Allon research presented at leading scientific symposium
VANCOUVER, May 14, 2012 /PRNewswire/ - Allon Therapeutics Inc. (TSX: NPC) announced today that a presentation given May 12 at the prestigious 12th International Stockholm / Springfield Symposium on Advances in Alzheimer Therapy featured new research with Allon's lead product candidate, davunetide, showing a prevention of neuronal cell death. This research was recently published in the International Journal of Alzheimer's Disease.
The article, "Tau and Caspase 3 as Targets for Neuroprotection", was authored by Professor Illana Gozes, scientific founder of Allon. Professor Gozes also gave the presentation at the Springfield Symposium. The manuscript and presentation describe the neuroprotective effect of davunetide at preventing apoptosis, or cell death, in different cellular pathways associated with neurodegenerative diseases like Alzheimer's and progressive supranuclear palsy (PSP), a devastating and progressive brain disease affecting movement, speech, and behaviour.
PSP is considered a tauopathy, involving the tau protein in brain cells. Allon has previously demonstrated, in both preclinical and clinical studies, that davunetide has an impact on the tau pathology. Davunetide is currently being tested in a pivotal clinical trial as a potential treatment for PSP which makes it the most advanced tau therapy in the world.
The Company believes that success in treating PSP with davunetide would define the opportunity to investigate davunetide in other tau-related diseases, such as Alzheimer's, subtypes of frontotemporal dementia, as well as other neurodegenerative diseases like schizophrenia and Parkinson's.
International Journal of Alzheimer's Disease is a peer-reviewed journal that publishes original research articles, review articles, and clinical studies in all areas of Alzheimer's disease. A downloadable version of the full article can be found at the following link: http://www.hindawi.com/journals/ijad/aip/493670/
The 12th International Stockholm / Springfield Symposium on Advances in Alzheimer Therapy is a bi-annual meeting that distinguishes itself from other scientific meetings of its kind for two reasons. It is the only international meeting that focuses entirely on the pharmacological therapy of Alzheimer's disease with particular emphasis on the discovery of new drugs. Also, the meeting is jointly organized by an American and two European research institutions.
Allon Therapeutics Inc. is a clinical-stage biotechnology company focused on bringing to market innovative central nervous system therapies. Allon's lead drug davunetide is proceeding in a pivotal clinical trial in an orphan indication, progressive supranuclear palsy (PSP), under a Special Protocol Assessment (SPA) with the U.S. Food and Drug Administration (FDA). The trial is fully enrolled and is expected to complete patient dosing and release top-line data by late 2012. This pivotal trial is based upon statistically significant human efficacy demonstrated in patients with amnestic mild cognitive impairment (a precursor to Alzheimer's disease), cognitive impairment associated with schizophrenia, and in positive biomarker data.
The Company is listed on the Toronto Stock Exchange under the trading symbol "NPC".
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